vesicobullous /ˈvɛsɪkoʊˌbʊləs/ adjective1 •Involving blisters of various sizes; that is, involving both vesicles and bullae.Vesicobullous diseases are characterised by the presence of vesicles or bullae at varying locations in the mucosa. — 2016 formsmore vesicobullous · most vesicobullous