vamoose /væˈmus/ verb3 •(slang) To run away (from); to flee.Speaking of the room in which I locked McIndoe — I will preface by saying that Mac "vamoosed that ranch" that very day and left me alone. — 1905 •(slang) To depart; go away.You can vamoose now—no question of having to get me out. We've arranged for messages. — 1934 •(slang) To hurry.He's got a wife who'll never give him a divorce. She knows about me, but it's still understood that when she decides to go to the ranch for a week or a weekend, I've got to vamoose. — 1966 formsvamoosed · vamoosing · vamooses