uppermost UK /ˈʌpəməʊst/US /ˈʌpɚˌmoʊst/adjective 3adverb 1 adjective3 •At or nearest the top of something.She couldn't reach the bowls on the uppermost shelf, so she made do with a mug. •Of top rank, importance, etc.This brings me to the uppermost problem for over-60-year-old lesbians. Loneliness. — 1990 •superlative form of upper: most upper. adverb1 •In the highest position.