underoxygenated adjective2 •Having insufficient oxygen.This concept assumes that all underoxygenated blood in the arteries comes from a true shunt, a passage through the lungs with no oxygenation. — 1983 •(figurative) Lacking vitality; lackluster.'Right now, you look very ... underoxygenated,' Perdu heard Max Jordan's voice say. — 2015 formsmore underoxygenated · most underoxygenated