ulcer UK /ˈʌlsə/US /ˈʌlsɚ/noun 3verb 1forms 3 noun3 •An open sore of the skin, eyes or mucous membrane, often caused by an initial abrasion and generally maintained by an inflammation and/or an infection. •Peptic ulcer."Worry never solved any problems. Only gives you ulcers." — 1957 •(figurative) Anything that festers and corrupts like an open sore; a vice in character. verb1 •To ulcerate. formsulcered · ulcering · ulcers