two-fisted adjective3 •Using both fists (or, figuratively, hands).[Tim] Henman's view is that [Andy] Murray must aim to have [Rafael] Nadal hitting two-fisted backhands on the run. — 2011 •(informal) Energetic, enthusiastic.I didn't want to do an ethnography, I wanted a two-fisted, action-packed noir. Because that's the kind of book I like to read. — 2011 •Inclined to fight, belligerent