twenty-two /ˌtwɛntiˈtuː/noun 1number 1forms 1 noun1 •A .22 calibre pistol or rifle.He wore a crazed expression / As he waded in the car / For some ammo and his sawn-off twenty-two. — 1992 number1 •The number after twenty-one and before twenty-three. Represented in Arabic digits as 22. formstwenty-twos