twatted adjective3 •(slang, vulgar) Extremely drunk, intoxicated •(slang, vulgar) Extremely or profoundly injured, usually as a result of deliberate action by another party. •[in compounds] (slang, vulgar) Having a particular sort of vagina or vulva.What kind of a cold-hearted bitch does that, You stinky twatted sadistic whore. — 2004 formsmore twatted · most twatted