transfenestration noun2 •(rare) The act of smashing through a window.I can see the thirst for new experiences, but a man’s better off sticking to a specialty, your own basically being transfenestration. — 1990 •(rare) A pathway through a fenestration.The megakaryocyte nuclei rarely make the transfenestration journey into the sinusoids and thence the blood. — 1998 formstransfenestrations