tighties noun[plural only]2 •(US, slang) Men's or boys' briefs.In addition, nowhere in the article did I sense that anyone is angry at Serrano or blaming the school for lax security or getting their tighties in a twiddle about this or that. — 2010 •(slang) Form-fitting cycling shorts.Cycle the workout tighties into your daily attire by balancing them with longer blazers or, another new trend, updated safari jackets. — 2019