tacrine /ˈtæ.kɹiːn/ noun1 •A synthetic drug used in Alzheimer's disease to inhibit the breakdown of acetylcholine by cholinesterase and thereby enhance neurological function.In the 1980s, Dr. Thal, a neurologist, helped lead successful clinical trials of tacrine, a cholinesterase inhibitor drug that was approved by the Food and Drug Administration in 1993. — 2007