syphilitic adjective 1noun 1forms 1 adjective1 •Of, relating to, or infected with syphilis.One can try hunting syphilitic treponemes directly by having skin irregularities […] biopsied and subjected to a silver-staining test. — 1988 noun1 •(old-fashioned) A person with syphilis.It was a syphilitic who lived alone in the shanty between the hole and the railroad yard, coming up to the street only to beg money for food and disinfectant with which to soak his rags. — 1952 formssyphilitics