synostosis UK /ˌsɪnɒˈstəʊsɪs/US /ˌsɪnɑˈstoʊsɪs/ noun2 •The healthy fusion of adjacent bones by the growth of a bony material.Examples of normal human developmental synostosis occur in the mandible and in the sacrum. •The abnormal bony fusion of a joint.Various synostoses are typical of Antley-Bixler syndrome. formssynostoses