synonymous UK /sɪˈnɒnɪməs/US /sɪˈnɑnɪməs/ adjective3 •Having a similar (sometimes identical) meaning. (See Usage notes below)He was not far wrong, for nothing strikes me more forcibly than the universal tendency to grumble: conversation and complaint are synonymous terms. — 1837 •Of, or being a synonym. •Such that both its forms yield the same sequenced protein.