suppository UK /səˈpɒzɪtəɹi/US /səˈpɑzɪˌtɔɹi/ noun1 •A medicine in the form of a small plug that is inserted into a bodily cavity, especially the rectum, vagina or urethra, where it melts at body temperature.He's smoother than a suppository, only his suppositories contain dynamite. — 1976 formssuppositories