substitution UK /ˌsʌb.stɪˈtʃuː.ʃən/US /ˌsʌb.stɪˈtu.ʃən/ noun4 •The act of substituting or the state of being substituted.In this football tournament, three substitutions can be made during the match. •The replacement of an atom, or group of atoms, in a compound, with another. •The expansion of the lexicon of a language by native means in correspondence to a foreign term. •A substitute or replacement.Gary is off this weekend, so Jeff will be his substitution. formssubstitutions