subclone noun 2verb 1forms 3 noun2 •A clone or descendant of a mutant occurring in a previous cloneDuring this process it is possible that additional mutations occur in one of the transformed cells, which then may result in a subclone of cells with a more aggressive behavior. — 1997 •A partial segment of DNA, cloven from a previously-cloned segment, which is then cloned into another vector verb1 •To reclone part of a previously-cloned DNA segment into a new vector(1) from the genomic library a clone of interest is selected and a small fragment is subcloned from one end of the clone — 2002 formssubcloned · subcloning · subclones