spleened adjective3 •angry; annoyed.Take me at the best, you shall not find a thing more spleened and choleric. — 1845 •Having splines or ridges.Combining, with the plain and spleened shaft and the cutters, the screw-threaded sleeves, for the purpose of adjusting said cutters, substantially as described. — 1871 •(no longer used) Deprived of the spleen.Prevention of blood parasites in seven spleened dogs. — 1957 formsmore spleened · most spleened