spay /speɪ/noun 1verb 1forms 4 noun1 •The act of spaying an animal.I was queasy about my first spay of a far-gone feral and left it up to my vet. — 1997 verb1 •To destroy or remove the ovaries or uterus (of a female animal) to prevent pregnancy.We’re having our cat spayed as we don’t want her having kittens. formsspade · spayed · spaying · spays