sluthole noun2 •(slang, vulgar) The anus; the vagina."You like that mancock in your sluthole, boy?” “Oh yeah, in my ass! I love it in my ass!” — 2010 •(slang, vulgar) A jerk, an asshole; something or someone contemptible.I can't go running around the sluthole motels looking for my own kid. Word would get out I was looking for a street whore. Sussman, you better find her. — 2007 formsslutholes