skull splitter noun2 •A severe headache or migraine.If you're lucky you'll get nauseous and sleepy and develop a skull-splitter of a headache. if you're not, the thing will simply explode. — 2004 •(slang) Any highly potent alcoholic beverage, mixed drink, or knock-off spirit designed to give the drinker a severe hangover.You don't want that at this time of day; that's a skull splitter. — 1985 formsskull splitters · skull-splitters