sister-in-law UK /ˈsɪs.tə.ɪn.lɔː/US /ˈsɪs.tɚ.ɪn.lɔ/ noun6 •A female relative of one's generation, separated by one degree of marriage. •The sister of one's spouse.Though they are not twins, my sister-in-law resembles my wife in almost every way. •The wife of one's sibling.My sister-in-law and my brother met while they were both on vacation in Jamaica. •Co-sister-in-law: The wife of one's sibling-in-law. •The wife of the sibling of one's spouse. •The sister of the spouse of one's sibling. formssister-in-laws · sisters in law · sisters-in-law