simpatico UK /sɪmˈpa.tɪ.kəʊ/US /sɪmˈpæ.tə.koʊ/ adjective2 •Having a compatible temperament or pleasing qualities.At first, I figured he was pretending to like things that women like to seem simpatico, a feminist hustle. But no, this guy really wanted to read “Northanger Abbey.” — 2025 •Compatible (with a person, thing, etc)."Basically, right now, you and math are just not...simpatico." — 2017 formsmore simpatico · most simpatico