set someone's teeth on edge verb2 •To irritate or strike as unpleasant.I can't stand his squeaky voice. It always sets my teeth on edge. •To cause a disagreeable tingling sensation in one's teeth, as when acids are brought into contact with them.For sounds, we see that the grating of a law, or any very harsh noise, will set the teeth on edge, and make all the body shiver — 1627 formssetting someone's teeth on edge · sets someone's teeth on edge