self-destruct verb 2noun 1forms 3 verb2 •To destroy oneself or itself.The submarine was primed to self-destruct. •To destroy or greatly damage one's position in a game, in one's work or career, in one's financial or social position, etc.If you attack with an energy level of only 30 you are going to self-destruct.Dating the boss is a bad move: if it goes badly, you could self-destruct. noun1 •A feature of a system whereby it destroys itself.They won't take any prisoners! Activate the self-destruct! formsself-destructed · self-destructing · self-destructs