second to none adjective 1noun 1 adjective1 •As good as the best, as in quality or reputation; inferior to no one else or to nothing else of the same kind.Second Merchant: How is the man esteemed here in the city? Angelo: Of very reverend reputation, sir, Of credit infinite, highly beloved, Second to none that lives here in the city. — 1594 noun1 •(slang) Heroin.The heroin, which police officials said had been measured at purity levels as high as 80 percent, is being sold under brand names like Unforgettable, Second to None, Black Beauty and Al Capone. — 1992