sclerosis

noun2

1. •
   The abnormal hardening of body tissues, such as an artery; the appearance of hardenings, indurations, lesions, nodules.

   • The “Euphoria” and “Grey’s Anatomy” actor announced on Thursday that he has been diagnosed with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s Disease. — 2025
2. •
   Inability to create change or excessive resistance to change.

   • Suppressing dissent dooms the society to sclerosis, decline and collapse. — 2019