sain /seɪn/ verb3 •To make the sign of the cross. •(no longer used) To make the sign of the cross on or over something or someone.Saining is the grand protection against them; a Shetlander always sains himself when passing by their hills. — 1828 •(no longer used) To bless, to keep from evil influence.Sain usǃ Sain us, oh Godǃ. formssained · saining · sains