run a train verb3 •(slang, vulgar) To have sex with someone multiple times in short succession. •(slang, vulgar) Synonym of gangbang: To have sex with someone as a line going one after the other.And we went upstairs and we ran a train on her. — 2008 •(slang) In online games, to lure large numbers of NPC enemies to a fortified enemy position in order to cause chaos and destruction formsran a train · running a train · runs a train