rubefacient /ɹu.bəˈfeɪ.ʃənt/adjective 1noun 1forms 3 adjective1 •Making red. noun1 •A substance for topical application that produces redness of the skin, e.g. by dilating the capillaries.The symptoms had diminished for a time, under the employment of rubefacients and cathartics; but the pain in the left side of the thorax returned in the evening of the 29th. — 1833 formsrubefacients · more rubefacient · most rubefacient