royal pain noun2 •(slang) Someone or something that is very annoying.And while the spine's no doubt a miraculous array of vertebrae, ligaments, muscle and nerve tissue, it can also be a royal pain in the... well, lower back region. — 1992 •(slang) A feeling of being very annoyed.He gave out a big yawn while he said that. Which is something that gives me a royal pain in the ass. — 1951 formsroyal pains