puke /pjuːk/noun 6verb 2forms 3phrases 1 noun6 •(informal) vomit.the puke saber … pulses light over rapidly changing wavelengths, apparently inducing "disorientation, nausea and even vomiting" — 2007 •(informal) A worthless, despicable person. •(slang, offensive) A person from Missouri."Pukes" and "suckers" had badly mauled the Saints, the first pummeling them from Missouri and the second from Illinois. — 2009 •(informal) A drug that induces vomiting."at 8 a.m. took a puke of vinum antimoniale; which operated very kindly; was very weak the remainder of the day." — 1776 •A very dark, dull, brownish-red color. •A fine grade of woolen cloth. verb2 •(informal) To vomit; to throw up; to eject from the stomach.Unfortunately, he could not hold it long enough till the end of the ride, so he puked on the bus seat. •(slang) To sell securities or investments at a loss, often under duress or pressure, in order to satisfy liquidity or margin requirements, or out of a desire to exit a deteriorating market. formspuked · puking · pukes Phrases with puke puke upTo vomit.