propofol UK /ˈpɹəʊ.pəf.ɒl/US /ˈpɹoʊ.pəˌfoʊl/ noun1 •A sedating and hypnotic agent C₁₂H₁₈O administered intravenously to induce and maintain anesthesia or sedation.The more likely scenario, the medical examiner testified, was that Dr. Murray had mistakenly administered a much larger dose of propofol than he realized, one that was lethal to his patient. — 2012 formspropofols