prion /ˈpɹiːɒn/noun 1/ˈpɹaɪən/ noun 1forms 1 noun1 •A self-propagating misfolded conformer of a protein that is responsible for a number of diseases that affect the brain and other neural tissue.Prion disease shares many features. — 1987 prion /ˈpɹaɪən/ noun1 •A petrel of the genera Pachyptila and Halobaena. formsprions