pox /pɑks/noun 3verb 1forms 3 noun3 •A disease characterized by skin eruptions (especially purulent ones) that may leave pockmarks. •(informal) Syphilis. •(figurative) A curse.A pox on him, he's a cat still. — 1604 verb1 •(old-fashioned) To infect with the pox, or syphilis. formspoxed · poxing · poxes