plagueful adjective2 •(no longer used) annoying; troublesome"Why now, what's all this my pretty lady?" cried Mr. Giles, perceiving her situation. "Why do you let those two plagueful things torment you so? Why don't you teach them to be better behaved." — 1814 •(no longer used) Abounding with plagues formsmore plagueful · most plagueful