pill popper noun4 •(informal, humorous) A person who enjoys or frequently takes medication in pill form.Well, you know, once Pop got into his sixties, he came to be a bit of a pill popper, what with the blood pressure and the blood sugar and the cholesterol and the arthritis. •(informal, disapproving) A person who frequently takes any other kind of pill, such as vitamins or illicit drugs.It's great when people are enthusiastic about health and wellness, but you just have to watch out for how hard the vitamin people sell you on the pricey supplements — they'll try to turn you into a pill popper. •(informal, offensive) Especially, someone with a frank substance use disorder who consumes a large amount of illicit pills, especially opioid street drug pills: synonym of pillhead.I wouldn't hang around in that part of town after dark, what with all the methheads and pill poppers. I'm not looking to get robbed. •A syringelike device for administering medicinal pills to animals. formspill poppers · pill-poppers