pick-me-up noun2 •Something that improves one's mood.A trip into town for lunch with my friend was a nice pick-me-up today. •(informal) A drink, often an alcoholic one, taken as a stimulant or sometimes as a hangover cure; a restorative, tonic or bracer.Strong tea is just the pick-me-up that I need right now.He brought a hip flask along, just in case he needs a little pick-me-up later. formspick-me-ups