phosphoribosyl pyrophosphate /ˌfɑs.foʊˌraɪ.boʊ.sɪlˌpaɪ.roʊˈfɑs.feɪt/ noun1 •A high-energy, activated sugar molecule derived from ribose 5-phosphate that acts as a key starting material for making and recycling nucleotides in cells. formsPRPP