palazzo UK /pəˈlæt͡səʊ/US /pəˈlɑt͡soʊ/ noun1 •A large, palatial urban building in Italy.Cecil Spenser's society—who soon shewed he could understand and enter into his views—became a source of great gratification, and his young countryman was almost domesticated at the palazzo. — 1831 formspalazzi · palazzos