ophidian /oʊˈfɪdi.ən/adjective 1noun 1forms 3 adjective1 •Of or pertaining to the suborder Serpentes; of, related to, or characteristic of a snake or serpent.The ophidian beast began to glow eerily, and Aaron could discern a fine webwork of veins and capillaries running throughout the creature's body. — 2009 noun1 •Any species of the suborder Serpentes; a snake or serpent.Vertebral structure is critical for the identification of fossil snakes, because vertebrae are among the most easily fossilized parts of ophidians. — 1997 formsophidians · more ophidian · most ophidian