one-hit verb2 •To defeat or kill in a single hit.No, one-hitting a dude with a basic spell isn't particularly challenging, but god does it feel good knowing I can only pull that off because I stacked rare Gifts in comically broken ways. — 2019 •To pitch so that the other team only makes a single hit.The Dodgers beat Arizona on Thursday afternoon, 6-3, with Chris Heisey hitting a grand slam and five relievers combining to one-hit the Diamondbacks over the final four innings. — 2015 formsone-hitting · one-hits