nocebo UK /nəʊˈsiː.bəʊ/US /noʊˈsi.boʊ/ noun[before a noun]1 •A substance which a patient experiences as harmful due to a previous negative perception, but which is in fact pharmacologically (medicinally) inactive.It is somewhat surprising that little attention has been drawn to the existence of the contrary effect [to the placebo] – which I may call the nocebo reaction. — 1961 formsnocebos