mysterium UK /mɪˈstɪəɹɪəm/US /mɪˈstɪɹiəm/ noun2 •(historical) Any of various unknown elements thought to make up existing forms of matter, or a substance seen as an elemental or pure form of something else.There are many such mysteria: milk is a mysterium of cheese and butter, and cheese in turn a mysterium of maggots, which were thought to form spontaneously in rotting food. — 2006 •(historical) The hypothetical source of a galactic radio emission at 1665 megahertz (later identified as due to hydroxyl radicals in interstellar space). formsmysteria