myogenic /mʌɪəˈdʒɛnɪk/ adjective2 •Originating in muscle tissue; specifically, pertaining to contractile activity that is produced by the muscles independent of any neural mechanism.Gaskell, using frogs' hearts, proved that the heartbeat was, as Haller had suggested, of myogenic origin. — 1997 •Forming muscle fibres; pertaining to myogenesis. formsmore myogenic · most myogenic