multifactorial adjective 2noun 1forms 1 adjective2 •Involving, or controlled by multiple factors.One of the under-reported dynamics during the coronavirus pandemic has been the collapse of One Nation’s vote. The reasons for this are likely multi-factorial. — 2021 •Involving multiple genetic or environmental factors. noun1 •A generalization of a factorial in which each element to be multiplied differs from the next by an integer (e.g. n(n-3)(n-6)(n-9)...). formsmultifactorials