mithridate UK /ˈmɪθrɪdeɪt/US /ˈmɪθrəˌdeɪt/ noun3 •(historical) Any of various historical medicines, typically an electuary compounded with various poison, believed to derive from Mithridates VI and to serve as a universal antidote.Auicen saythe; There be certeyne medicins... which wyl not suffre poyson to approche nere the harte, as triacle and Metridate. — 1528 •(figurative, no longer used) Synonym of cure.The contemplation was a mithridate to a pestered conceipted minde. — 1587 •(no longer used, rare) Ellipsis of mithridate mustard. formsmithridates