misfortune UK /mɪsˈfɔːtʃuːn/US /mɪsˈfɔɹt͡ʃən/ noun2 •An instance of bad luck, an undesirable event such as an accident.She had to come to terms with a number of misfortunes. •Synonym of bad luck.The worst tour I have ever had the misfortune to experience. formsmisfortunes