mindscrew noun 1verb 1forms 3 noun1 •(slang) Something that destabilizes, confuses, or manipulates a person's mind.It's in television that Abrams, arguably more than Spielberg, has nudged the medium forward, with "Felicity," then "Alias" and finally the mindscrew of "Lost." — 2009 verb1 •To destabilize, confuse, or manipulate a person's mind. formsmindscrewed · mindscrewing · mindscrews