microbe UK /ˈmaɪkɹəʊb/US /ˈmaɪkɹoʊb/ noun1 •Any microorganism; (loosely, nonscientifically) especially, a harmful bacterium.We humans and other complex animals are full of microbes, gajillions of them. People have so many that microbe cells living in our bodies outnumber our own vastly. — 2015 formsmicrobes